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Organometallics in Process Chemistry

Organometallics in Process Chemistry PDF Author: Thomas J. Colacot
Publisher: Springer Nature
ISBN: 3030279618
Category : Science
Languages : en
Pages : 314

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Book Description
This volume gives an overview of the applications of organometallic chemistry in process chemistry relevant to the current topics in synthetic chemistry. This volume starts with an introduction on the historical development of organometallics in process chemistry and is followed by chapters dealing with the last five years’ development in various organometallic reaction types such as the challenging cross coupling process, construction of 3.1.0 bicycles, pressure and transfer hydrogenations of historically challenging compounds such as esters, utilization of carbon dioxide for making organic compounds by flow process, drug synthesis and metal detection and scavenging in the finished APIs. A chapter by Colacot et.al., is also devoted to the process development and structural understanding of organometallic catalysts with particular emphasis to LnPd(0) catalysts. An academia – industry collaborated chapter on the use of water as a solvent for organometallic processes is included in this book.

Organometallics in Process Chemistry

Organometallics in Process Chemistry PDF Author: Thomas J. Colacot
Publisher: Springer Nature
ISBN: 3030279618
Category : Science
Languages : en
Pages : 314

View

Book Description
This volume gives an overview of the applications of organometallic chemistry in process chemistry relevant to the current topics in synthetic chemistry. This volume starts with an introduction on the historical development of organometallics in process chemistry and is followed by chapters dealing with the last five years’ development in various organometallic reaction types such as the challenging cross coupling process, construction of 3.1.0 bicycles, pressure and transfer hydrogenations of historically challenging compounds such as esters, utilization of carbon dioxide for making organic compounds by flow process, drug synthesis and metal detection and scavenging in the finished APIs. A chapter by Colacot et.al., is also devoted to the process development and structural understanding of organometallic catalysts with particular emphasis to LnPd(0) catalysts. An academia – industry collaborated chapter on the use of water as a solvent for organometallic processes is included in this book.

Organometallics in Process Chemistry

Organometallics in Process Chemistry PDF Author: Rob Larsen
Publisher: Springer Science & Business Media
ISBN: 9783540016038
Category : Science
Languages : en
Pages : 316

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Book Description
The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.

Organometallic Chemistry in Industry

Organometallic Chemistry in Industry PDF Author: Thomas J. Colacot
Publisher: John Wiley & Sons
ISBN: 3527819193
Category : Science
Languages : en
Pages : 336

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Book Description
Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

Surface and Interfacial Organometallic Chemistry and Catalysis

Surface and Interfacial Organometallic Chemistry and Catalysis PDF Author: C. Copéret
Publisher: Springer Science & Business Media
ISBN: 9783540264965
Category : Science
Languages : en
Pages : 312

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Book Description
With contributions by numerous experts

Organic Synthesis

Organic Synthesis PDF Author: Michael B Smith
Publisher: Academic Press
ISBN: 0128008075
Category : Science
Languages : en
Pages : 1106

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Book Description
Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. PowerPoint© presentations and answer keys are also available online to support instructors. Fully revised and updated throughout, and teorganized into 19 chapters for a more cogent and versatile presentation of concepts Includes reaction examples taken from literature research reported between 2010-2015 Features new full-color art and new chapter content on process chemistry and green organic chemistry Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Lecture presentations and other useful material for qualified course instructors

Organometallic Chemistry and Catalysis

Organometallic Chemistry and Catalysis PDF Author: Didier Astruc
Publisher: Springer Science & Business Media
ISBN: 3540461299
Category : Science
Languages : en
Pages : 608

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Book Description
This volume covers both basic and advanced aspects of organometallic chemistry of all metals and catalysis. In order to present a comprehensive view of the subject, it provides broad coverage of organometallic chemistry itself. The catalysis section includes the challenging activation and fictionalization of the main classes of hydrocarbons and the industrially crucial heterogeneous catalysis. Summaries and exercises are provides at the end of each chapter, and the answers to these exercises can be found at the back of the book. Beginners in inorganic, organic and organometallic chemistry, as well as advanced scholars and chemists from academia and industry will find much value in this title.

Process Chemistry in the Pharmaceutical Industry

Process Chemistry in the Pharmaceutical Industry PDF Author: Kumar Gadamasetti
Publisher: CRC Press
ISBN: 9780824719814
Category : Medical
Languages : en
Pages : 514

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Book Description
Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers—offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, Process Chemistry in the Pharmaceutical Industry is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.

Applications of Organometallic Chemistry in the Preparation and Processing of Advanced Materials

Applications of Organometallic Chemistry in the Preparation and Processing of Advanced Materials PDF Author: J.F. Harrod
Publisher: Springer Science & Business Media
ISBN: 9401103372
Category : Technology & Engineering
Languages : en
Pages : 355

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Book Description
In the ten years since the scientific rationale for the design, synthesis and application of inorganic and organometallic polymers (IOPs) was first conceptualised, we have witnessed the first tentative exploration of IOPs as precursors to new materials, with efforts focusing on the design and synthesis of novel ceramic precursors. Developing expertise led to precursor studies combined with the characterisation of the transformation processes that occur when IOPs are converted to ceramic materials. Now at maturity, the science presented in this volume reveals the polymer precursor approach to materials synthesis together with examples of processing ceramic shapes for a range of mechanical properties, the development of sophisticated, noninvasive analytical techniques, and IOP design rationales relying on well-defined processing-property relationships. The production of multifunctional IOPs is described, providing ion conductivity, gas sensing, bioactivity, magnetic properties, etc., combined with processability. The existence of well-defined IOPs and the exquisite control that can be exerted on sol-gel systems now provide access to such a variety of mixed organic-organometallic and/or inorganic hybrid systems that their exploitation is likely to develop into an entirely new field of materials chemistry. Future exciting avenues of research are also being opened up with the advent of buckyballs, Met-Cars, dopable preceramics, rigid-rod organometallics, and molecular tinkertoys.

Organometallic Oxidation Catalysis

Organometallic Oxidation Catalysis PDF Author: Franc Meyer
Publisher: Springer
ISBN: 3540372105
Category : Science
Languages : en
Pages : 253

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Book Description
In many of the processes of oxidation catalysis, species with metal-carbon bonds are formed as key intermediates, and these processes represent the primary focus of this volume. An important aspect covered by some of the contributors is the use of organic ligands to achieve efficient oxidation catalysis. Each volume of "Topics in Organometallic Chemistry" provides a comprehensive summary and critical overview of a specific topic in organometallic chemistry.

Applied Homogeneous Catalysis with Organometallic Compounds

Applied Homogeneous Catalysis with Organometallic Compounds PDF Author: Boy Cornils
Publisher: John Wiley & Sons
ISBN: 3527651764
Category : Science
Languages : en
Pages : 1872

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Book Description
The completely revised third edition of this four-volume classic is fully updated and now includes such topics as as CH-activation and multicomponent reactions. It describes the most important reaction types, new methods and recent developments in catalysis. The internationally renowned editors and a plethora of international authors (including Nobel laureate R. Noyori) guarantee high quality content throughout the book. A "must read" for everyone in academia and industry working in this field.